Hu Chen

This study shows that astrocyte-expressed STAT3 maintains glutamate transporter levels and promotes ethanol consumption in male mice.

The paper shows that different isoforms of CIC interact with paralogs ATXN1 and ATXN1L, leading to distinct phenotypes and explaining tissue-specific vulnerability in neurological diseases.

scDeepVariant improves germline variant calling in scRNA-seq by integrating population allele frequency data, outperforming existing methods in precision, recall, and rare variant detection.

The paper identifies a disrupted mitochondrial-purine metabolism link in MECP2 Duplication Syndrome across multiple models, linking it to neurodevelopmental issues.

This paper introduces DiRL, a reinforcement learning framework that enables single-cell foundation models to model and control cellular differentiation by optimizing multi-step perturbation strategies.

This study compares 11 AAV serotypes for transduction efficiency and specificity in murine olfactory sensory neurons using nasal inoculation.

Lemur is a single-cell foundation model for Drosophila melanogaster that enables fine-tuning-free cell-type annotation across diverse tissues and conditions.

The paper introduces glmSMA, a computational algorithm that predicts cell locations by integrating scRNA-seq data with spatial-omics reference atlases, demonstrating its ability to recapitulate spatial gene expression and anatomical structures.

This study uses Nanopore direct RNA sequencing to analyze RNA processing differences between honey bee queen and worker castes during larval development, revealing complex alternative splicing and dynamic isoform expression.

This study presents a high-quality genome assembly of a single parasitoid wasp using ultra-low input DNA, demonstrating the feasibility of de novo assembly with minimal DNA.

This study identifies estrogen receptor α's role in enhancing ethanol excitation of VTA dopamine neurons and binge drinking in female mice, highlighting sex-specific mechanisms in alcohol use disorder.

This study shows that disrupting perineuronal nets in the insula increases sensitivity to bitter-tastant adulterated alcohol and enhances insula activation during aversion-resistant drinking.