Conserved Cis-Acting Range Extender Element Mediates Extreme Long-Range Enhancer Activity in Mammals
Grace Bower, Ethan W. Hollingsworth, Sandra H. Jacinto, Joshua A. Alcantara, Ben Clock, Kaitlyn Cao, Mandy Liu, Adam Dziulko, Ana Alcaina‐Caro, Qianlan Xu, Dorota Skowronska‐Krawczyk, Javier López-Rı́os, Diane E. Dickel, Anaïs F. Bardet, Len A. Pennacchio, , Evgeny Z. Kvon
The paper identifies a conserved cis-acting element, REX, that enables extreme long-range enhancer-promoter interactions in mammals by increasing the genomic interaction range of enhancers.
Nature · Jul 2, 2025Peer-reviewedGenomics