Qianlan Xu

ECHOS enables spatial epigenome profiling at subcellular resolution by combining high-resolution imaging and high-throughput sequencing, revealing distinct gene regulatory logics and epigenetic changes in human tissues.

The paper identifies a conserved cis-acting element, REX, that enables extreme long-range enhancer-promoter interactions in mammals by increasing the genomic interaction range of enhancers.

PHOTON captures subcellular RNA localization using imaging and sequencing, revealing m6A's role in stress granule mRNA partitioning.

This study shows that repeated stress in young mice accelerates retinal aging at the transcriptional and epigenetic levels, highlighting the importance of early intervention for age-related eye diseases.

The paper maps the subcellular localization of PKA subunits in the retina, revealing distinct patterns and functional nonredundancy, with C{beta} localized to mitochondria and linked to neurodegenerative diseases.

This study shows that elovl2 is essential for proper lipid composition and visual function in zebrafish, as its inactivation leads to altered lipid levels and visual behavior.

The paper shows that removing senescent cells early in a mouse model of ocular hypertension protects retinal ganglion cells from loss and preserves visual function.

This study investigates 3D genome reorganization during mouse spermatogenesis, revealing dynamic changes in TADs, chromatin loops, and transcriptional regulation.