Author

Grace Bower

University of California, IrvineORCID 0000-0003-1104-604XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ana Alcaina‐CaroiD· 2 shared Axel ViseliD· 2 shared Ben ClockiD· 2 shared Diane E. DickeliD· 2 shared Evgeny Z. KvoniD· 2 shared Javier López-Rı́osiD· 2 shared Len A. PennacchioiD· 2 shared Sandra H. JacintoiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Ana Alcaina‐CaroORCID

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3 papers

Recent·Most cited

GenomicsNaturePeer-reviewedJul 2, 2025

Conserved Cis-Acting Range Extender Element Mediates Extreme Long-Range Enhancer Activity in Mammals

Grace Bower, Ethan W. Hollingsworth, Sandra H. Jacinto…·Evgeny Z. Kvon

The paper identifies a conserved cis-acting element, REX, that enables extreme long-range enhancer-promoter interactions in mammals by increasing the genomic interaction range of enhancers.

50 citationstop 1%

mouseChIP-seq

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GenomicsNature GeneticsPeer-reviewedMar 20, 2024

Increased Enhancer-Promoter Interactions during Developmental Enhancer Activation in Mammals

Zhuoxin Chen, Valentina Snetkova, Grace Bower…·Evgeny Z. Kvon

The paper examines 3D enhancer-promoter interactions during mammalian development, finding that most enhancers bypass neighboring genes and show tissue-specific conformations with increased interactions upon activation.

86 citationstop 1%

mouseHi-C

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Synthetic BiologyNature CommunicationsPeer-reviewedJan 12, 2021

Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems

Timothy C. Yu, Winnie L. Liu, Marcia S. Brinck…·Guillaume Urtecho

The paper profiles 8,269 IPTG-inducible promoters to model gene expression and identify optimal promoter architectures for predictable transcriptional control.

60 citations

E. coliDNA methylation

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