Dorota Skowronska‐Krawczyk

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

This study uses multimodal optical imaging to reveal spatial metabolic changes in aging mouse retinas, showing altered NADH/NADPH ratios, collagen remodeling, and lipid dynamics.

The paper identifies pituitary macrophages as hormone-producing immune cells that regulate gonadotropin secretion through CXCL5-CXCR2-MAPK signaling in female mice.

This study shows Reelin regulates retinal lamination by coordinating neuronal positioning and Müller glia scaffold maturation in mice.

The paper identifies yeast-derived lipids that extend lifespan in Drosophila by remodeling metabolism in the gut and brain, enhancing tissue homeostasis and communication.

This study shows the Greenland shark retains a functional visual system adapted to dim light, with intact rod-based vision genes and no retinal degeneration despite its age.

The paper identifies a conserved cis-acting element, REX, that enables extreme long-range enhancer-promoter interactions in mammals by increasing the genomic interaction range of enhancers.

This study identifies ELOVL2 as a key lipid metabolism enzyme that regulates B cell progenitor development and immune aging in mice and humans.

This study develops a novel Cre-inducible mouse model of myocilin glaucoma that replicates key human disease features, showing impaired axonal transport precedes retinal ganglion cell loss.

This study shows that supplementing aged mice with 24:5n-3, a product of ELOVL2, improves visual function and reduces AMD-related protein accumulation, suggesting ELOVL2 as a therapeutic target for age-related vision loss.

This study shows that activating soluble adenylyl cyclase (sAC) protects retinal ganglion cells from oxidative stress by preserving mitochondrial function and structure.

This study shows that repeated stress in young mice accelerates retinal aging at the transcriptional and epigenetic levels, highlighting the importance of early intervention for age-related eye diseases.

The paper maps the subcellular localization of PKA subunits in the retina, revealing distinct patterns and functional nonredundancy, with C{beta} localized to mitochondria and linked to neurodegenerative diseases.

This study shows that elovl2 is essential for proper lipid composition and visual function in zebrafish, as its inactivation leads to altered lipid levels and visual behavior.

This study shows that loss of AKAP1 leads to Drp1 dephosphorylation, mitochondrial fragmentation, and RGC dysfunction in glaucoma, suggesting AKAP1 as a therapeutic target.

This study shows that ELOVL2 regulates aging in the mouse retina by affecting fatty acid elongation and visual function, with potential therapeutic implications for age-related eye diseases.

The paper shows that removing senescent cells early in a mouse model of ocular hypertension protects retinal ganglion cells from loss and preserves visual function.