SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1
Fangyuan Dong, Kang He, Shan Zhang, Kaiyuan Song, Luju Jiang, Li-Peng Hu, Qing Li, Xueli Zhang, Naiqi Zhang, Bo-Tai Li, L.-L. Zhu, Jun Li, Mingxuan Feng, Yunchen Gao, Jie Chen, , Shu‐Heng Jiang
This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.
Cell Reports · Oct 1, 2024Peer-reviewedCancer Biology