Helen He Zhu

This study shows citalopram reduces hepatocellular carcinoma by modulating C5aR1+ tumor-associated macrophages and enhancing CD8+ T cell anti-tumor immunity.

This study identifies glucokinase (GCK) as a metabolic enzyme that regulates lineage plasticity in neuroendocrine prostate cancer through its interaction with AKT1.

moPepGen identifies non-canonical peptides from genetic and transcriptomic data across species and technologies by generating them in linear time.

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

The paper introduces BigRNA, an RNA foundation model that predicts RNA biology from DNA sequence and identifies therapeutic effects of SBOs on gene expression and splicing.

The paper identifies a basal stem cell subpopulation in the prostate using lineage tracing, functional analysis, and single-cell RNA-seq, showing Zeb1+ cells are multipotent prostate basal stem cells.

This study shows that E-cadherin connects cell polarity and spindle orientation in prostate epithelial cells, preventing carcinogenesis.