Qing Li

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

Mechanical cues of extracellular matrix determines tumor innervation

This study identifies ECM stiffness as a driver of tumor innervation and shows that targeting integrin β1/YAP1 mechanotransduction reduces TIN in preclinical and clinical settings.