p57Kip2 regulates embryonic haematopoietic stem cell numbers by controlling the size of the sympathoadrenal progenitor pool
Chrysa Kapeni, Leslie Nitsche, Alastair Morris Kilpatrick, Nicola K. Wilson, Kankan Xia, Bahar Mirshekar-Syahkal, Camille Malouf, Berthold Göttgens, Kristina Kirschner, Simon R. Tomlinson, Katrin Ottersbach
The paper shows p57Kip2 limits HSC numbers by restricting SNS progenitor size and catecholamine secretion in the AGM region via β2-adrenergic signaling.
bioRxiv · Sep 13, 2021 · PreprintDevelopmental Biology