Katrin Ottersbach

Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche.

This study identifies miR-93 as a key regulator of KMT2A-rearranged B-ALL survival in the CNS niche through transcriptomic and immune profiling in a murine model.

Endothelial-specific Gata3 expression is required for haematopoietic stem cell generation

This study shows that endothelial-specific Gata3 expression is required for the maturation of haemogenic endothelial cells into haematopoietic stem cells during the endothelial-to-haematopoietic transition.

p57Kip2 regulates embryonic haematopoietic stem cell numbers by controlling the size of the sympathoadrenal progenitor pool

The paper shows p57Kip2 limits HSC numbers by restricting SNS progenitor size and catecholamine secretion in the AGM region via β2-adrenergic signaling.

Single cell transcriptome analysis reveals markers of naive and lineage-primed hematopoietic progenitors derived from human pluripotent stem cells.

The paper identifies markers of naive and lineage-primed hematopoietic progenitors from hPSCs using single-cell RNA sequencing and functional assays.