Author

Leslie Nitsche

MRC Centre for Regenerative MedicineORCID 0000-0002-0312-7467Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

Katrin OttersbachiD· 3 shared Berthold GöttgensiD· 2 shared Camille MaloufiD· 2 shared Nicola K. WilsoniD· 2 shared A FidanzaiD· 1 shared Alasdair DuguidiD· 1 shared Alastair Morris KilpatrickiD· 1 shared Bahar Mirshekar-SyahkaliD· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersDevelopmental Biology

Katrin OttersbachORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 3, 2024

Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche.

Alasdair Duguid, Camille Malouf, Leslie Nitsche…·Katrin Ottersbach

This study identifies miR-93 as a key regulator of KMT2A-rearranged B-ALL survival in the CNS niche through transcriptomic and immune profiling in a murine model.

DOI 10.1101/2024.12.03.626602

mousebulk RNA-seq

𝕏 PostBluesky

Developmental BiologybioRxivPreprintSep 14, 2021

Endothelial-specific Gata3 expression is required for haematopoietic stem cell generation

Nada M. Zaidan, Evangelia Diamanti, Leslie Nitsche…·Katrin Ottersbach

This study shows that endothelial-specific Gata3 expression is required for the maturation of haemogenic endothelial cells into haematopoietic stem cells during the endothelial-to-haematopoietic transition.

DOI 10.1101/2021.09.14.460344

mouseexperimental assay

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Developmental BiologybioRxivPreprintSep 13, 2021

p57Kip2 regulates embryonic haematopoietic stem cell numbers by controlling the size of the sympathoadrenal progenitor pool

Chrysa Kapeni, Leslie Nitsche, Alastair Morris Kilpatrick…·Katrin Ottersbach

The paper shows p57Kip2 limits HSC numbers by restricting SNS progenitor size and catecholamine secretion in the AGM region via β2-adrenergic signaling.

DOI 10.1101/2021.09.13.459835

mousebulk RNA-seq

𝕏 PostBluesky