Controlled Delivery of a Neurotrophic Factor in the Adult Mouse Brain Using Engineered Microglia
Rohan Hofland, Marta Grońska-Pęski, Hiroko Nobuta, Nicolas Buitrago, Karan Malhotra, Jean M. Hébert, J. Tiago Gonçalves
This study demonstrates the use of engineered microglia to deliver BDNF to the adult mouse brain, controlled by doxycycline, with enhanced engraftment via a constitutively active CSF1R mutant.
bioRxiv · Oct 6, 2025 · PreprintNeuroscience