NeurosciencebioRxivPreprint
Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid beta-degrading enzyme, in brain
Per Nilsson, Karin Margareta Sörgjerd, Naomasa Kakiya…·Takaomi C. Saido
This study identifies SST1 and SST4 as redundant regulators of neprilysin, a key amyloid beta-degrading enzyme, and shows that targeting these receptors reduces Aβ pathology and improves cognition in an AD mouse model.
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