Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid beta-degrading enzyme, in brain
Per Nilsson, Karin Margareta Sörgjerd, Naomasa Kakiya, Hiroki Sasaguri, Naoto Watamura, Makoto Shimozawa, Satoshi Tsubuki, Zhulin Zhou, Raúl Loera‐Valencia, Risa Takamura, Misaki Sekiguchi, Aline Petrich, Stefan Schulz, Takashi Saito, Bengt G. Winblad, Takaomi C. Saido
This study identifies SST1 and SST4 as redundant regulators of neprilysin, a key amyloid beta-degrading enzyme, and shows that targeting these receptors reduces Aβ pathology and improves cognition in an AD mouse model.
bioRxiv · May 9, 2020 · PreprintNeuroscience