An aged human bone marrow mesenchymal niche causes impaired function of human hematopoietic stem cells under regeneration-induced stress
Ani Grigoryan, Ruba Abdelrahman, Wong Sik Seo, Alejandro Gracia-Garcia, Vadim Sakk, Antigoni Karavelaki, Karin Maria Danzer, Christian Haupt, Hubert Schrezenmeier, Moritz Oltmanns, Heiko Reichel, Hartmut Geiger, Paul Emile Bourgine
This study shows that aged human bone marrow mesenchymal stromal cells impair hematopoietic stem cell function under regeneration stress by promoting myeloid bias.
bioRxiv · Oct 28, 2026 · PreprintCell Biology