Ani Grigoryan

This study shows that aged human bone marrow mesenchymal stromal cells impair hematopoietic stem cell function under regeneration stress by promoting myeloid bias.

This study uses multi-omics profiling to identify chromatin remodeling and lncRNA changes in BM-MSCs during early endochondral ossification priming.

This paper introduces OssiGel, a novel engineered matrix that enables the formation of autologous ossicles from AML patient samples, supporting AML cell engraftment and recapitulating patient-specific cellular interactions.

This study identifies a Cdc42-Borg4-Sep7 axis that regulates HSC polarity and function by controlling the polar distribution of these proteins and affecting engraftment potential and LMPP frequency.