Paul Emile Bourgine

An aged human bone marrow mesenchymal niche causes impaired function of human hematopoietic stem cells under regeneration-induced stress

This study shows that aged human bone marrow mesenchymal stromal cells impair hematopoietic stem cell function under regeneration stress by promoting myeloid bias.

Multi-omics profiling links epigenetic and lncRNA changes to early human endochondral ossification priming

This study uses multi-omics profiling to identify chromatin remodeling and lncRNA changes in BM-MSCs during early endochondral ossification priming.

Engineering autologous ossicles for the personalized modeling of acute myeloid leukemia

This paper introduces OssiGel, a novel engineered matrix that enables the formation of autologous ossicles from AML patient samples, supporting AML cell engraftment and recapitulating patient-specific cellular interactions.

Engineered and decellularized human cartilage graft exhibits intrinsic immuno-evasive properties and full skeletal repair capacity

This study engineers and decellularizes human cartilage grafts, demonstrating their immuno-evasive properties and ability to repair skeletal defects in rats.

Human mitochondrial transfer modeling reveals biased delivery from mesenchymal-to-hematopoietic stem cells

The paper develops iMSOD-mito, a tool to model human mesenchymal-to-hematopoietic mitochondrial transfer, showing preferential transfer to hematopoietic stem cells and functional impacts.

Kinematic analysis of cell lineage reveals coherent and robust mechanical deformation patterns in zebrafish gastrulation

The paper analyzes cell lineage data to reveal mechanical deformation patterns in zebrafish gastrulation, showing coherent and robust biomechanical behavior.