Hartmut Geiger

This study shows that aged human bone marrow mesenchymal stromal cells impair hematopoietic stem cell function under regeneration stress by promoting myeloid bias.

This study identifies mitochondrial dysfunction and impaired osteogenic capacity as key features of stress-induced osteoblast senescence using in vitro models and transcriptomic analysis.

The paper shows that CASIN inhibits CDC42, reversing PD-related transcriptional changes and affecting MAPK and PI3K/AKT pathways in an aging mouse model.

The paper uses single-cell RNA sequencing to analyze somatic mutations in HSCs and finds age-related clonal expansion and transcriptional divergence.

This study shows that the level of myeloid skewing in blood correlates with biological aging and disease in mice and humans.

This study shows that aging processes drive Parkinson's Disease in a mouse model, independent of alpha-synuclein oligomers, by targeting CDC42 activity.

This study identifies cell type-specific molecular consequences of mosaic structural variants in hematopoietic stem and progenitor cells across aging.

The paper develops an epigenetic clock for mice using age-associated CpGs conserved between mouse strains and humans, showing high correlation with chronological age.

This study identifies a Cdc42-Borg4-Sep7 axis that regulates HSC polarity and function by controlling the polar distribution of these proteins and affecting engraftment potential and LMPP frequency.

This study compares pyrosequencing, ddPCR, and BBA-seq for epigenetic age prediction in mice, finding that pyrosequencing and ddPCR show slightly better CpG age correlation than BBA-seq.

This study develops an in-silico model to explore how hematopoietic stem cells (HSCs) respond to varying demands and aging, showing that internal feedback between HSCs and progenitors explains homeostasis and aging-related changes.

This study develops a three-CpG site-based epigenetic age predictor for mice using DNA methylation data, showing it can accurately estimate chronological age in blood samples.