FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes
Christopher Yanucil, Dominik Kentrup, Xueyi Li, Alexander Grabner, Karla J. Schramm, Eliana Cecilia Martinez, Jinliang Li, Isaac D. Campos, Brian A. Czaya, Kylie Heitman, David G. Westbrook, Adam R. Wende, Alexis J. Sloan, Johanna M. Roche, Alessia Fornoni, , Christian Faul
This study shows that FGF21-FGFR4 signaling in cardiac myocytes causes concentric hypertrophy in diabetic mice, suggesting it may contribute to HFpEF and that FGFR4 blockade could be a therapeutic target.
Scientific Reports · May 5, 2022Peer-reviewedMolecular Biology