Non-Canonical Heme Oxygenase-1 Function in Hematopoietic Stem Cell Homeostasis and Aging
Monika Żukowska, Izabella Skulimowska, Mateusz Sypniewski, Anna Kusienicka, Mateusz Tomczyk, Sylwester Mosiołek, Jan Morys, Ewa Werner, Karolina Hajduk, Dounia Djeghloul, Michèle Goodhardt, Józef Dulak, Alicja Jozkowicz, Krzysztof Szade
This study shows that HO-1 has a non-canonical, cell-intrinsic role in regulating HSC homeostasis, differentiation, and aging by affecting genome maintenance, apoptotic signaling, and RNA metabolism.
bioRxiv · Jan 28, 2026 · PreprintCell Biology