This study shows that HO-1 has a non-canonical, cell-intrinsic role in regulating HSC homeostasis, differentiation, and aging by affecting genome maintenance, apoptotic signaling, and RNA metabolism.

bioRxiv · Jan 28, 2026 · PreprintCell Biology

Dose- and time-dependent effects of cobalt protoporphyrin IX on granulocyte mobilization and metabolic markers in mice

Aleksandra Bednarz, Paweł Kożuch, Kacper Kowalski, Izabella Skulimowska, Neli Kachamakova‐Trojanowska, Jadwiga Filipek-Gorzała, Patrycja Kwiecińska, Raquel García-García, Kinga Gawlińska, Kinga Mależyna, Andrzej Kubiak, Natalia Bryniarska, Alicja Józkowicz, Krzysztof Szade, Agata Szade

This study evaluates the dose- and time-dependent effects of CoPP on granulocyte mobilization and metabolic markers in mice, finding a dose-dependent mobilizing effect with mild side effects.

Pharmacological Reports · Jul 9, 2025Peer-reviewedPharmacology & Toxicology

Novel insights into the regulation of chemerin expression: role of acute-phase cytokines and DNA methylation

Kamila Kwiecień, Piotr Brzoza, Maciej Bąk, Paweł Majewski, Izabella Skulimowska, Kamil Bednarczyk, Joanna Cichy, Mateusz Kwitniewski

This study identifies acute-phase cytokines and DNA methylation as regulators of chemerin expression in different cell types.

Scientific Reports · Aug 13, 2020Peer-reviewedMolecular Biology