Krzysztof Szade

Non-Canonical Heme Oxygenase-1 Function in Hematopoietic Stem Cell Homeostasis and Aging

This study shows that HO-1 has a non-canonical, cell-intrinsic role in regulating HSC homeostasis, differentiation, and aging by affecting genome maintenance, apoptotic signaling, and RNA metabolism.

Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy

This study shows that laminin-α2 secreted by muscle stem cells is critical for their expansion and regeneration, and its loss leads to muscle stem cell dysfunction in LAMA2-related muscular dystrophy.

Effect of heme oxygenase-1 on the expression of interferon-stimulated genes

This study investigates how heme oxygenase-1 (HO1) affects interferon-stimulated gene (ISG) expression in response to various stressors, finding that TNF is a key inducer and HO1 influences nuclear retention of inflammatory transcription factors.

Dose- and time-dependent effects of cobalt protoporphyrin IX on granulocyte mobilization and metabolic markers in mice

This study evaluates the dose- and time-dependent effects of CoPP on granulocyte mobilization and metabolic markers in mice, finding a dose-dependent mobilizing effect with mild side effects.

AFM-based nanoscale characterization of physical interaction within hematopoietic stem cells niche at single-cell level

The paper uses atomic force microscopy to measure physical interactions in the hematopoietic stem cell niche, revealing differences in adhesion forces between mesenchymal stromal cells and hematopoietic stem cells.