A new universal chimeric-antigen receptor (CAR)- fragment antibody binder (FAB) split system for cancer immunotherapy
Ainhoa Arina, Edwin J. Arauz, Karolina Warzecha, Elham Masoumi, Annika M. Sääf, Łukasz Widło, Tomasz Ślężak, Aleksandra Zieminska, Karolina Dudek, Zachary P. Schaefer, Maria Łęcka, Svitlana Usatyuk, Ralph R. Weichselbaum, Anthony A. Kossiakoff
This paper introduces a modular CAR-Fab platform that improves cancer immunotherapy by enabling rapid target redirection and reducing antigen loss variant escape.
Science Advances · Jul 4, 2025Peer-reviewedBioengineering