Author

Maria Łęcka

Wrocław University of Science and TechnologyORCID 0000-0001-8104-4803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

Ainhoa ArinaiD· 1 shared Aleksandra Zieminska· 1 shared Annika M. Sääf· 1 shared Anthony A. KossiakoffiD· 1 shared Bartosz Dołęga-KozierowskiiD· 1 shared Boris TurkiD· 1 shared Edwin J. Arauz· 1 shared Elham MasoumiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

Ainhoa ArinaORCID

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2 papers

Recent·Most cited

Cancer BiologyJournal of Medicinal ChemistryPeer-reviewedJul 1, 2026

Engineering cathepsin S selective chemical probes and antibody-drug conjugates through substrate profiling with unnatural amino acids

Maria Łęcka, Oliwia Gorzeń, Natalia Ćwilichowska-Puślecka…·Marcin Poręba

The paper develops selective chemical probes and antibody-drug conjugates for cathepsin S by profiling substrate specificity with unnatural amino acids and validates their efficacy in cancer models.

2 citationstop 3%

humanproteomics

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BioengineeringScience AdvancesPeer-reviewedJul 4, 2025

A new universal chimeric-antigen receptor (CAR)- fragment antibody binder (FAB) split system for cancer immunotherapy

Ainhoa Arina, Edwin J. Arauz, Karolina Warzecha…·Anthony A. Kossiakoff

This paper introduces a modular CAR-Fab platform that improves cancer immunotherapy by enabling rapid target redirection and reducing antigen loss variant escape.

5 citations

humanproteomics

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