PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
Tarik Husremović, Vanessa Meier, Lucas Piëch, Katharina M. Siess, Sumire Antonioli, Irina Grishkovskaya, Nikoleta Kircheva, Silvia Angelova, Karoline Wenzl, Andreas Brandstätter, Jiri Veis, Fran Miočić-Stošić, Dorothea Anrather, Markus Hartl, Linda Truebestein, , Thomas A. Leonard
This study reveals that PHLPP2 is a pseudophosphatase with no catalytic activity, challenges its role as a tumor suppressor, and identifies its non-catalytic functions in Akt signaling.
Proceedings of the National Academy of Sciences · Apr 1, 2025Peer-reviewedBiochemistry