David Haselbach

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22

This paper reveals the structural basis of NSD2 degradation via SCF-FBXO22 recruitment, showing how aldehyde-based degraders induce conformational changes for covalent binding and efficient protein degradation.

A multivalent adaptor mechanism drives the nuclear import of proteasomes

The paper identifies AKIRIN2 as a multivalent adaptor protein that coordinates proteasome nuclear import through a stepwise assembly of importin clusters.

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.

The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.

In vivo kinetics of protein degradation by individual proteasomes

This study uses live-cell single-molecule imaging to show that proteasome substrate processing depends on engagement mode, not just substrate identity or folding.

Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape

The paper shows electrostatic changes in the Exo70 subunit led to its dissociation from the exocyst complex, enabling functional divergence in plants.

Structural basis for the ubiquitin chain recognition of the human 26S proteasome

The paper determines how the human 26S proteasome distinguishes between K48-linked and K11/K48-branched ubiquitin chains through structural analysis and functional studies.

PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor

This study reveals that PHLPP2 is a pseudophosphatase with no catalytic activity, challenges its role as a tumor suppressor, and identifies its non-catalytic functions in Akt signaling.

PITHD1: An Endogenous Inhibitor of the 26S Proteasome During Cellular Dormancy

The paper identifies PITHD1 as an endogenous inhibitor of the 26S proteasome in dormant cells, revealing a triple-lock mechanism that prevents protein degradation during cellular dormancy.

A dual ribosomal system in the zebrafish soma and germline

The paper identifies a dual ribosomal system in zebrafish, showing maternal and somatic ribosomes are both active and can form hybrid ribosomes in the embryo.