Author

Egon Ogris

Max Perutz LabsORCID 0000-0001-5950-9264Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Jiri VeisiD· 2 shared Andreas BrandstätteriD· 1 shared Arminja Nadine KettenbachiD· 1 shared Bob MeeuseniD· 1 shared Bojan ŽagrovićiD· 1 shared Brooke L. BraueriD· 1 shared Camilla B. Chan· 1 shared Christoph BockiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Jiri VeisORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor

Tarik Husremović, Vanessa Meier, Lucas Piëch, Katharina M. Siess, Sumire Antonioli, Irina Grishkovskaya, Nikoleta Kircheva, Silvia Angelova, Karoline Wenzl, Andreas Brandstätter, Jiri Veis, Fran Miočić-Stošić, Dorothea Anrather, Markus Hartl, Linda Truebestein, , Thomas A. Leonard

This study reveals that PHLPP2 is a pseudophosphatase with no catalytic activity, challenges its role as a tumor suppressor, and identifies its non-catalytic functions in Akt signaling.

Proceedings of the National Academy of Sciences · Apr 1, 2025Peer-reviewedBiochemistry

A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions

Bob Meeusen, Sara M. Ambjørn, Jiri Veis, Rachel C. Riley, Gianmatteo Vit, Brooke L. Brauer, Mads H. Møller, Elora C. Greiner, Camilla B. Chan, Melanie Bianca Weisser, Dimitriya Hristoforova Garvanska, Hao‐Jie Zhu, Norman E. Davey, Arminja Nadine Kettenbach, Egon Ogris, Jakob Nilsson

The paper identifies CYB5R4 as an evolutionarily conserved reductase that activates PP4 and PP6 by reducing their catalytic metal ions, essential for cell viability under oxidative stress.

bioRxiv · Feb 12, 2025 · PreprintCell Biology