Markus Hartl

RAStoERK: a reference interaction atlas for insights into signaling and disease

The paper creates a comprehensive reference map of the RAS/RAF/MEK/ERK pathway interactomes and their mutation-driven rewiring, revealing new interactions and disease links.

Myopathy-causing variants of PYROXD1 converge on impaired RNA ligation

This study identifies how PYROXD1 myopathy-causing variants impair RNA ligation by affecting RTCB activation and protein stability.

A complex of MAST1 and 14-3-3 regulates Tau phosphorylation in the developing cortex

This study identifies MAST1 and 14-3-3 as regulators of Tau phosphorylation in the developing cortex through interactions and phosphorylation events.

Dbf4-dependent kinase promotes meiotic DNA end resection through cyclin-dependent kinase 12 and DNA-2 in Caenorhabditis elegans

This study identifies a DDK/CDK-12/DNA-2 signaling axis that promotes meiotic DNA end resection in C. elegans, preventing aberrant recombination outcomes.

Carbon Dioxide Controls Fungal Fitness and Skin Tropism of Candida auris

This study identifies a carbonic sensing pathway (CSP) in Candida auris that enhances drug resistance and skin colonization through mechanisms involving ROS response, cell wall remodeling, and energy metabolism.

PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor

This study reveals that PHLPP2 is a pseudophosphatase with no catalytic activity, challenges its role as a tumor suppressor, and identifies its non-catalytic functions in Akt signaling.

A causal model of ion interference enables assessment and correction of ratio compression in multiplex proteomics

The paper develops a causal model to assess and correct ratio compression caused by ion interference in multiplex proteomics data.

Pre-mRNA fate decision safeguards the fidelity of the inflammatory response

The paper shows that TTP regulates mRNA degradation by licensing its assembly on pre-mRNA, ensuring controlled inflammatory response termination.

GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage

This study identifies GSE1 as a component of the HDAC1/CoREST complex involved in DNA damage response, revealing its role in DDR signaling and histone modification regulation.

amica: an interactive and user-friendly web-platform for the analysis of proteomics data

amica provides a user-friendly web platform for proteomics data analysis, offering quality control, differential expression, and network analysis with minimal user input.