Global Proteomics Investigation of SAMT-247 Targets: An Antiviral Thioester that Acetylates Zinc Finger Proteins
Connor P. Jewell, Andrew J. Perciaccante, Kate Brown, Tapan Kumar Maity, Jerry C. Dinan, Massimiliano Bissa, Mohammad Arif Rahman, Genoveffa Franchini, Daniel H. Appella, Lisa M. Miller Jenkins
This study identifies SAMT-247's off-target effects on zinc-coordinating proteins in immune cells, showing increased metabolic and immune responses in stimulated THP-1 cells.
bioRxiv · Apr 30, 2026 · PreprintCell Biology