Author
The University of Texas Southwestern Medical CenterORCID 0000-0001-5660-1444Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Jerry C. Dinan, James W. McCormick, Rishi Soni…·Kimberly A. Reynolds
This study shows that inserting a domain into a protein's sector-connected surface increases the likelihood of evolving allosteric regulation, while non-sector-connected sites are less evolvable.
Connor P. Jewell, Andrew J. Perciaccante, Kate Brown…·Lisa M. Miller Jenkins
This study identifies SAMT-247's off-target effects on zinc-coordinating proteins in immune cells, showing increased metabolic and immune responses in stimulated THP-1 cells.
James W. McCormick, Jerry C. Dinan, Marielle AX Russo…·Kimberly A. Reynolds
This study investigates how domain insertion in a synthetic enzyme fusion enables light-induced allosteric regulation through localized conformational changes and bidirectional domain coupling.