SMARCA4 is essential for early-stage tumor development but its loss promotes late-stage cancer progression in small-cell lung cancer
Nicole A. Kirk, Jin Ng, Kate-Lin Ly, Young Ho Ban, Godfrey A. Dzhivhuho, Jinho Jang, Kyung-Pil Ko, Michael S. Kareta, Jae‐Il Park, Anthony Nicholas Karnezis, Anish Thomas, Kate D. Sutherland, Kwon-Sik Park
This study shows SMARCA4 is important for early tumor development in SCLC but its loss promotes late-stage cancer progression through altered tumor-NK cell interactions.
bioRxiv · May 21, 2025 · PreprintCancer Biology