Kyung-Pil Ko

Spatiotemporal Transcriptomic Dissection Uncovers Age-Dependent Deceleration of Esophageal Cell Differentiation

This study uses single-cell transcriptomics to analyze age-related changes in esophageal stem cell dynamics and differentiation, finding that impaired differentiation, not stem cell self-renewal, drives aging-related homeostasis decline.

Single-cell lineage trajectory defines CDK inhibitor-sensitive cells-of-origin in esophageal squamous cell cancer

This study identifies CDK inhibitor-sensitive cells-of-origin in ESCC using single-cell trajectory analysis and drug repurposing, revealing key regulators and therapeutic vulnerabilities.

Deciphering precursor cell dynamics in esophageal preneoplasia via genetic barcoding and single-cell transcriptomics

This study uses genetic barcoding and single-cell transcriptomics to trace lineage dynamics of esophageal preneoplastic cells, identifying a high-plasticity progenitor population and molecular markers for early detection of esophageal squamous cell cancer.

Comparative single-cell transcriptomics of orthotopic and subcutaneous gastric tumors reveal immune and stromal heterogeneity

This study compares immune and stromal differences between orthotopic and subcutaneous gastric tumors using scRNA-seq, finding distinct TME features in each model.

SMARCA4 is essential for early-stage tumor development but its loss promotes late-stage cancer progression in small-cell lung cancer

This study shows SMARCA4 is important for early tumor development in SCLC but its loss promotes late-stage cancer progression through altered tumor-NK cell interactions.

Actin dysregulation induces immune evasion via oxidative stress-activated PD-L1 in gastric cancer

This study shows that CRACD inactivation in gastric cancer leads to immune evasion via oxidative stress-activated PD-L1, suggesting HIF1 and PD-L1 as therapeutic targets.