Single-cell phenomics through integrated imaging and molecular profiling
Johannes Bues, Joern Pezoldt, Camille L G Lambert, Benjamin D. Hale, Elisa Bugani, Ramón Viñas, Timothee Ferrari, Nadia Grenningloh, Vincent Gardeux, Shuo Wen, Caroline Wandinger, Maximilian Kohnen, Romina Augustin, Katharina Eckstein, Assia Ouanaya, , Bart Deplancke
The paper introduces IRIS, a platform integrating high-resolution imaging and single-cell RNA sequencing to link morphology with transcriptomes, revealing new nuclear-ER architectures in CD8+ T cells.
bioRxiv · Nov 28, 2025 · PreprintImmunology