Vincent Gardeux

This study shows that growth factor-free synthetic matrices reveal donor-specific differences in human skeletal progenitor cell osteogenic potential, which are masked by conventional methods.

The scFAIR Consortium develops a unified metadata schema and portal to improve FAIRness of scRNA-seq data through standardized annotations and semantic search.

The paper introduces IRIS, a platform integrating high-resolution imaging and single-cell RNA sequencing to link morphology with transcriptomes, revealing new nuclear-ER architectures in CD8+ T cells.

The paper introduces scTF-seq, a method to study TF dose-dependent reprogramming in mouse MSCs, revealing heterogeneity in cell fate and TF sensitivity.

The paper shows that mitochondrial metabolic activity determines ER stress signaling activation in neurons, conserved across Drosophila and human brains.

EXTRA-seq quantifies enhancer-promoter communication in endogenous contexts, revealing the TATA-box's role in modulating expression and improving gene expression prediction when integrated with deep learning models.

DGRPool is a web tool that harmonizes DGRP phenotyping data to enable GWAS and PheWAS, revealing correlations between longevity and other traits.

The paper evaluates CM mapping tools, shows cell type-specific CRE interactions, and demonstrates how non-coding variants affect CM activity in a cell type-specific manner.

This study profiles GnRH neurons in mice to uncover developmental gene expression patterns linked to human reproductive processes.

The paper identifies 'context-only' transcription factors that contribute to enhancer communication by forming cooperative environments with pioneer factors.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

This study investigates how OCT4 and SOX2 regulate chromatin accessibility in mouse embryonic stem cells across the cell cycle, showing their independent and cooperative roles in maintaining pluripotency.

The paper investigates the hourglass pattern of Evo-Devo by showing reduced expression variability during the phylotypic stage in Drosophila melanogaster, linked to histone modification-mediated noise control.

This paper introduces BRB-seq, a cost-effective bulk RNA-seq method that matches TruSeq performance and enables high-throughput transcriptomics with low-quality RNA.

ASAP provides a web-based platform for analyzing and visualizing scRNA-seq data, enabling users to perform analysis and visualization without requiring computational expertise.