Benjamin D. Hale

Single-cell phenomics through integrated imaging and molecular profiling

The paper introduces IRIS, a platform integrating high-resolution imaging and single-cell RNA sequencing to link morphology with transcriptomes, revealing new nuclear-ER architectures in CD8+ T cells.

Multiplexed high-throughput immune cell imaging reveals molecular health-associated phenotypes

The paper uses multiplexed imaging and deep learning to analyze immune cell phenotypes across human cohorts, revealing associations with age, gender, and health markers.

Regional protein expression in human Alzheimer’s brain correlates with disease severity

This study identifies region-specific protein expression changes in human Alzheimer’s brains, revealing disease severity gradients and protective profiles in the cerebellum.