The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer
Helen E. Grimsley, Katherine Courtemanche, Shane Cox, Anthony Calder, Niamh McDermott, Xin Pei, Sharma Aman, Jackson Bright, Nadeem Riaz, Jeremy S. Setton, Mehmet A. Orman, Simon N. Powell
The paper identifies the 9-1-1 complex as essential for stabilizing ssDNA gaps in BRCA2-deficient cells through an ATR-independent mechanism, highlighting its role in preventing pathological expansion and DNA damage.
Molecular Cell · Oct 1, 2026Peer-reviewedMolecular Biology