Nadeem Riaz

The paper identifies the 9-1-1 complex as essential for stabilizing ssDNA gaps in BRCA2-deficient cells through an ATR-independent mechanism, highlighting its role in preventing pathological expansion and DNA damage.

The paper identifies TIE CD8+ T cell clonotypes associated with prolonged survival in pancreatic cancer patients and links resistance to stromal and immune barriers.

The paper identifies MDF, a repair scar linked to POLQ-driven error-prone repair, as a marker of immune-responsive HRD pancreatic cancer with increased neoantigens and favorable clinical outcomes.

This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.

This study demonstrates that RNA transcripts can serve as templates for double-strand break repair in human cells, identifying DNA polymerase-zeta as a key enzyme and revealing genomic scars associated with this process.

This study identifies gene modules associated with melanoma immunotherapy response using dynamic Ollivier-Ricci curvature analysis of gene expression data.

The paper identifies three novel complex structural variation patterns in cancer genomes using genome graph analysis across 2,833 tumor WGS.

This study examines mtDNA copy number variation across 21 solid tumor types using next-generation sequencing, finding significant depletion in bladder and kidney cancers and correlations with metabolic pathway expression and specific mutations.