Mehmet A. Orman

The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer

The paper identifies the 9-1-1 complex as essential for stabilizing ssDNA gaps in BRCA2-deficient cells through an ATR-independent mechanism, highlighting its role in preventing pathological expansion and DNA damage.

Parallel evolution of chimeric genes in microbial evolution experiments

This paper reports the parallel evolution of chimeric genes in Escherichia coli through genomic deletions, suggesting they are more common and potentially adaptive than previously thought.

Glycerol-Driven Energy and Proteostasis Underpin Antibiotic Tolerance in Escherichia coli

This study identifies glycerol metabolism as critical for antibiotic tolerance in stationary-phase Escherichia coli by maintaining energy homeostasis and proteostasis.

UV-B-Induced DNA Repair Mechanisms and Their Effects on Mutagenesis and Culturability in Escherichia coli

This study investigates UV-B-induced DNA repair mechanisms in E. coli, finding a dose-dependent trade-off between mutagenesis and culturability.

The Diverse Phenotypic and Mutational Landscape Induced by Fluoroquinolone Treatment

This study examines how fluoroquinolone treatment induces diverse phenotypic and mutational changes in E. coli, showing that tolerance and resistance can evolve independently with varied fitness effects.

The Role of c-Jun Signaling in Cytidine Analog-Induced Cell Death in Melanoma

This study investigates how melanoma cells respond to cytidine analogs like gemcitabine, showing that c-Jun signaling is involved in drug-induced cell death and cycle arrest.

Unraveling CRP/cAMP-Mediated Metabolic Regulation In Escherichia coli Persister Cells

This study investigates metabolic rewiring in Escherichia coli persister cells, showing that Crp/cAMP shifts metabolism to oxidative phosphorylation, with energy metabolism critical for survival.

Systematic Design of Pulse Dosing to Eradicate Persister Bacteria

This paper develops a method for systematically designing periodic pulse dosing strategies to eradicate persister bacteria using mathematical models and experimental validation.