A FGF2-mediated incoherent feedforward loop inducesErk inhibition and promotes naive pluripotency
Borzo Gharibi, Emanuel Gonçalves, Buhe Nashun, Alex Montoya, Katherine Mankalow, Stephanie Strohbuecker, Rahuman S. Malik‐Sheriff, Alessandro Ciccarelli, Joana Carvalho, Emma L. Nye, Holger Kramer, Ian R. Rosewell, Petra Hájková, Pedro Beltrão, Silvia D. M. Santos
This study identifies an FGF2-mediated incoherent feedforward loop that inhibits Erk and promotes naive pluripotency in ES cells and embryos.
bioRxiv · Nov 11, 2020 · PreprintDevelopmental Biology