Petra Hájková

This study identifies HIRA SUMOylation as a cause of chromatin instability in aging oocytes, leading to reduced fertility, and shows similar defects in human oocytes.

This study reveals a unique 3D genome architecture in premeiotic gonadal germ cells, linked to epigenetic reprogramming and loss of TADs, alongside DNA demethylation.

This paper establishes a defined feeder-free system to convert human PGC-like cells to pluripotent stem cells, tracking transcriptional and epigenomic transitions using multi-omic analysis.

This study shows PROSER1 regulates DNA demethylation through dual mechanisms, balancing gene expression and preventing developmental malformations.

This study investigates epigenetic reprogramming in pig primordial germ cells, identifying similarities with human germline processes and potential for transgenerational epigenetic inheritance.

The paper shows that the TBPL2/TFIIA complex establishes the oocyte transcriptome by using a specific TSS recognition code through oocyte-specific promoter usage.

This study identifies an FGF2-mediated incoherent feedforward loop that inhibits Erk and promotes naive pluripotency in ES cells and embryos.

The paper identifies global regulatory transitions at core promoters during mammalian germline development, showing a shift from somatic to maternal promoter codes in oogenesis.

The paper shows that DNA methylation persists in Cryptococcus neoformans despite the loss of a de novo methyltransferase, with methylation patterns maintained through replication and natural selection.

This study shows TET2 regulates microglial inflammatory responses through NF-κB-dependent pathways and metabolic changes, suggesting it as a target for neurodegenerative diseases.

SLIC-CAGE enables high-resolution transcription start site mapping using nanogram-level total RNA, significantly reducing the required input compared to existing CAGE methods.

This study shows that 2i conditions increase transcriptional heterogeneity in pluripotent stem cells, driven by signaling pathways and negative feedback loss.