The paper tracks mesodermal cell migration and lineage during mouse gastrulation, revealing distinct progenitor behaviors and fate allocation in cardiac development.

The EMBO Journal · May 13, 2025Peer-reviewedDevelopmental Biology

Mycobacterium tuberculosis ESX-T7SS impacts the 3D architecture of tuberculous lesion in susceptible mice

Caroline G. G. Beltran, Jurgen Kriel, Stefan Marc Botha, Margaret B. Nolan, Alessandro Ciccarelli, Ben Loos, Maximiliano Gabriel Gutierrez, Gerhard Walzl

This paper uses 3D imaging to show that M. tuberculosis ESX-1 affects granuloma architecture in infected mice.

Disease Models & Mechanisms · Mar 26, 2025Peer-reviewedMicrobiology

Sympathetic neuron-derived NPY protects from obesity by sustaining the mural progenitors of thermogenic adipocytes.

Yitao Zhu, Lu Yao, Ana Luisa Gallo-Ferraz, Bruna Bombassaro, Marcela Reymond Simoes, Ichitaro Abe, Jing Wen Chen, Gitalee Sarker, Alessandro Ciccarelli, Linna Zhou, Carl Lee, Davi Sidarta-Oliveira, Noelia Martínez‐Sánchez, Michael Loran Dustin, Cheng Zhan, , Ana Isabel Domingos

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

Nature · Aug 28, 2024Peer-reviewedPhysiology

A FGF2-mediated incoherent feedforward loop inducesErk inhibition and promotes naive pluripotency

Borzo Gharibi, Emanuel Gonçalves, Buhe Nashun, Alex Montoya, Katherine Mankalow, Stephanie Strohbuecker, Rahuman S. Malik‐Sheriff, Alessandro Ciccarelli, Joana Carvalho, Emma L. Nye, Holger Kramer, Ian R. Rosewell, Petra Hájková, Pedro Beltrão, Silvia D. M. Santos

This study identifies an FGF2-mediated incoherent feedforward loop that inhibits Erk and promotes naive pluripotency in ES cells and embryos.

bioRxiv · Nov 11, 2020 · PreprintDevelopmental Biology