A cleaved cytosolic FOXG1 promotes excitatory neurogenesis by enhancing mitochondrial translation.
Hannah Bruce, Kathryn Adamson, Gessica Goncalves, Marnie E. Halpern, Clinton A. L. Monfries, Oniz Suleyman, Lourdes Osuna Almagro, Fursham Hamid, Katherine R. Long, Corinne Houart
The paper shows that a cleaved cytosolic FOXG1 enhances mitochondrial translation and promotes excitatory neurogenesis, offering a new therapeutic target for mitochondrial disorders.
bioRxiv · Aug 13, 2024 · PreprintNeuroscience