Fursham Hamid

Physiological Cryptic Last Exon Splicing Generates Regulated and Functional Transcript Isoforms Across Vertebrates

The paper identifies cryptic last exons (CLEs) in vertebrates and shows they generate regulated, functional transcript isoforms with developmental roles.

An integrated pipeline to count individual transcripts with single-cell resolution

HCR3.0 RNA-FISH linked to RS-FISH spot detection labels transcripts in C. elegans embryos, larvae and adults, and yields per-neuron counts of short insulin-like peptide mRNAs in L2 larvae.

Distinct signaling center and progenitor identity dynamics initiate human forebrain patterning

The paper identifies human-specific features of telencephalic patterning in early development using single-cell transcriptomics and spatial imaging, showing delayed ventral SHH signaling and enhanced anterior FGF signaling compared to mice.

Dlx2 reprograms the transcriptome and laminar position of glia-derivedAscl1-induced interneurons

This study shows that a modified Ascl1 variant, Ascl1SA6, can reprogram glial cells into interneurons that resemble canonical cortical interneurons when combined with Dlx2, improving their laminar positioning.

A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons

This study identifies a molecular switch driven by neuronal activity and PGC-1 that promotes the maturation of parvalbumin interneurons during postnatal development.

Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations

The paper identifies cadherins as mediators of cell type-specific inhibitory connectivity between pyramidal neurons and interneurons in the neocortex.

Regulation of parvalbumin interneuron plasticity by neuropeptide-encoding genes

This study identifies how neuropeptide-encoding genes regulate synaptic plasticity in parvalbumin interneurons in the adult mouse neocortex.

Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals

This study identifies somatic mutations in cleavage and polyadenylation signals of tumour suppressor genes as a novel class of noncoding drivers in cancer.

A cleaved cytosolic FOXG1 promotes excitatory neurogenesis by enhancing mitochondrial translation.

The paper shows that a cleaved cytosolic FOXG1 enhances mitochondrial translation and promotes excitatory neurogenesis, offering a new therapeutic target for mitochondrial disorders.

Alternative splicing coupled to nonsense-mediated decay coordinates downregulation of non-neuronal genes in developing neurons

The paper develops an R package to analyze AS-NMD events in neuronal differentiation and finds that NS-CEs regulate gene downregulation in developing neurons.

Cortical wiring by synapse-specific control of local protein synthesis

The paper identifies a signaling pathway that regulates local protein synthesis at specific synapses on PV+ interneurons in the mouse cortex.

Neural stem cells alter nucleocytoplasmic partitioning and accumulate nuclear polyadenylated transcripts during quiescence

The paper identifies altered nucleocytoplasmic partitioning and nuclear accumulation of polyadenylated transcripts as conserved features of quiescence in neural stem cells.

Cytoplasmic pool of spliceosome protein SNRNP70 regulates the axonal transcriptome and development of motor connectivity

The paper shows that SNRNP70 in axons regulates transcript stability and splice variants, affecting motor connectivity development.

A conserved role for SFPQ in repression of pathogenic cryptic last exons

This study identifies SFPQ's role in repressing cryptic last exons, showing its conservation across species and relevance to neurodegenerative diseases.