Katherine R. Long

This study uses single-cell RNA sequencing to track the maturation of human choroid plexus organoids and identifies a stage-dependent window of developmental plasticity.

The paper shows that 25-hydroxycholesterol disrupts brain endothelial function by altering cholesterol metabolism, linking viral infection to brain vessel dysfunction in intracerebral haemorrhage.

This study identifies human-specific morphoregulatory signatures in basal radial glia that drive neocortex evolution through comparative chromatin and transcriptional profiling.

The paper introduces DeepCellMap, a deep learning tool for analyzing spatial cellular organization in developing brains, revealing microglial phenotypes and spatial clustering patterns.

The paper shows that a cleaved cytosolic FOXG1 enhances mitochondrial translation and promotes excitatory neurogenesis, offering a new therapeutic target for mitochondrial disorders.

This study shows that primate-specific EPIREGULIN expression enhances basal progenitor proliferation in the developing neocortex, contributing to increased brain size across species.

This study finds elevated Myo-inositol levels in the developing brains of individuals with Down Syndrome, detectable as early as 10 weeks post conception.

This study shows Sox9 regulates basal progenitor proliferation and gliogenesis in the developing neocortex through ECM induction and integrin signaling.

This study shows YAP activity is necessary and sufficient for basal progenitor proliferation and abundance in the developing neocortex, linking it to neocortical expansion during evolution.

This study shows that human-specific ARHGAP11B increases proliferative basal radial glia and expands the neocortex in developing ferrets.