Rett Syndrome astrocytes disrupt neuronal activity and cerebral organoid development through transfer of dysfunctional mitochondria
Danielle L. Tomasello, M. Inmaculada Barrasa, David V. Mankus, Katia I Alarcon, Abigail K. R. Lytton‐Jean, X. Shawn Liu, Rudolf Jaenisch
This study shows that RTT astrocytes release dysfunctional mitochondria, disrupting neuronal activity and cerebral organoid development through impaired energy metabolism and mitochondrial dysfunction.
Scientific Reports · Sep 4, 2024Peer-reviewedNeuroscience