Author

M. Inmaculada Barrasa

Whitehead Institute for Biomedical ResearchORCID 0000-0003-3393-4814Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Rudolf JaenischiD· 2 shared Abigail K. R. Lytton‐JeaniD· 1 shared Alexsia L. Richards· 1 shared Allison M. WilliamsiD· 1 shared Ami KobayashiiD· 1 shared Anna M. KrichevskyiD· 1 shared Anthony FlamieriD· 1 shared Bradley T. HymaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Rudolf JaenischORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 10, 2026

tRNA-derived fragments elevated in Alzheimer's disease facilitate Tau aggregation

Ami Kobayashi, Chung-Ta Han, Lien Nguyen…·Anna M. Krichevsky

This study identifies tRNA-derived fragments (tRFs) as key regulators of Tau aggregation in Alzheimer's disease and shows their potential as therapeutic targets.

1 citation

humanmouse

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NeuroscienceScientific ReportsPeer-reviewedSep 4, 2024

Rett Syndrome astrocytes disrupt neuronal activity and cerebral organoid development through transfer of dysfunctional mitochondria

Danielle L. Tomasello, M. Inmaculada Barrasa, David V. Mankus…·Rudolf Jaenisch

This study shows that RTT astrocytes release dysfunctional mitochondria, disrupting neuronal activity and cerebral organoid development through impaired energy metabolism and mitochondrial dysfunction.

27 citationstop 2%

humanbulk RNA-seq

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Molecular BiologyVirusesPeer-reviewedFeb 25, 2023

LINE1-mediated reverse transcription and genomic integration of SARS-CoV-2 mRNA detected in virus-infected but not in viral mRNA-transfected cells

Liguo Zhang, Punam Bisht, Anthony Flamier…·Rudolf Jaenisch

The paper detects SARS-CoV-2 retrotransposition into host genomes via LINE1 in infected cells but not in transfected cells, using WGS and TagMap methods.

20 citations

humanwhole-genome sequencing

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