David V. Mankus

Mitochondrial amino acid export preserves mitochondrial volume at the egg-to-embryo transition

The paper identifies Sfxn1-3's role in regulating mitochondrial volume during the egg-to-embryo transition by controlling amino acid export and osmotic balance.

A 3D in vitro model of the human hepatobiliary junction

This paper develops a 3D in vitro model of the human hepatobiliary junction that recapitulates bile flow and dysfunction under hypoxia-reoxygenation, offering insights into biliary pathophysiology.

Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model

The paper constructs a 3D human brain model integrating multiple cell types to study Alzheimer's Disease mechanisms linked to APOE4.

Rett Syndrome astrocytes disrupt neuronal activity and cerebral organoid development through transfer of dysfunctional mitochondria

This study shows that RTT astrocytes release dysfunctional mitochondria, disrupting neuronal activity and cerebral organoid development through impaired energy metabolism and mitochondrial dysfunction.

Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells

The paper shows that mammalian cells maintain a constant surface area-to-volume ratio as they grow by increasing plasma membrane folding.

Ribosome-Associated Vesicles promote activity-dependent local translation in neurons

The paper identifies Ribosome-Associated Vesicles (RAVs) as dynamic platforms that facilitate activity-dependent local translation in neurons by transporting ribosomes to distal processes.