Protease-activated receptor 1-mediated matrix metalloprotease signalling in sensory neurons
Katie J Williams, Giulia Galimberti, James P. Higham, Emily Overington, Charity N. Bhebhe, Tim Raine, Paola Sacerdote, David Colin Bulmer
This study identifies MMP3, MMP8, and MMP9 as inducers of Ca2+ release in DRG neurons via PAR1 and PLC activation, revealing a novel role for MMP signaling in sensory neurons during inflammation.
bioRxiv · Aug 20, 2025 · PreprintNeuroscience