David Colin Bulmer

This study shows that inhibiting TYK2 reduces IL-6 and OSM-induced calcium signaling in murine sensory neurons, suggesting therapeutic potential for pain management in IBD.

The paper investigates how cromolyn, a GPR35 agonist, inhibits PGE2-induced TRPV1 sensitization in sensory neurons, supporting GPR35 as an anti-nociceptive target.

This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.

This paper introduces a bioelectronic implant for recording neural activity in the distal colon of freely-moving rats, demonstrating its ability to capture electrophysiological responses and colonic activity related to food intake and stress.

This study identifies MMP3, MMP8, and MMP9 as inducers of Ca2+ release in DRG neurons via PAR1 and PLC activation, revealing a novel role for MMP signaling in sensory neurons during inflammation.

The paper identifies IL-17's role in enhancing pain sensitivity in the gut via PI3K-dependent mechanisms in ulcerative colitis.

This study shows TRPV4 activation in the colon increases afferent activity via mucosal release of ATP and glutamate, suggesting a target for visceral pain treatment.

This study investigates how inflammatory mediators affect TRPM3 channel function in mouse sensory neurons and finds that IL-1β and TNF potentiate TRPM3 without changing its expression, while pharmacological blockade does not alleviate inflammatory pain in a specific model.

This study correlates mouse digging behavior with human pain experience, showing that digging deficits reflect pain levels and that meloxicam is more effective than gabapentin in alleviating these deficits.

This study identifies Angiotensin II as a pro-nociceptive mediator in IBD by showing increased Agt expression and AT1 receptor activation in colonic neurons.

The paper shows that KV7 channel openers, but not SK/IK channel openers, reduce colonic afferent responses to noxious stimuli, suggesting KV7 channels as potential targets for abdominal pain treatment.

This study shows TNFα sensitizes colonic nociceptors via TNFR1 and p38 MAPK, enhancing responses to capsaicin and noxious distension.

This study shows that TNF-α activated fibroblast-like synoviocytes sensitize knee neurons in vitro, contributing to inflammatory pain in arthritis.

This study investigates acid and inflammatory sensitivity of colonic afferent nerves in naked mole-rats compared to mice, showing differential responses to acid and bradykinin.

This study shows galanin inhibits colonic afferent responses to mechanical and inflammatory stimuli via GalR1, with effects absent in inflamed tissue.