Tim Raine

The Human Gut Cell Atlas v1.0: A Unified, Community-Built Reference of Cellular Diversity Across the Gut

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn's Disease Pathogenesis.

The paper identifies molecular signatures of Crohn's disease using scRNA-seq data from terminal ileal biopsies, highlighting key cell types and pathways involved in disease pathogenesis.

Resolving inflammatory bowel disease risk variants to genes and cell types

This study identifies 619 IBD risk signals, resolves 81 high-confidence variants, and prioritizes 664 candidate effector genes using GWAS, eQTL, and exome sequencing.

Exome sequencing directly implicates 68 genes in inflammatory bowel disease

This study uses exome and genome sequencing to identify 68 genes directly associated with inflammatory bowel disease, providing clearer genetic insights and therapeutic targets.

GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception

This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.

Single-cell genetics identifies cell-type-specific effector genes across complex traits and diseases

The paper uses single-cell eQTL data to identify cell-type-specific effector genes associated with 69 diseases and 31 biomarker traits, revealing distinct immune cell contributions to disease.

Protease-activated receptor 1-mediated matrix metalloprotease signalling in sensory neurons

This study identifies MMP3, MMP8, and MMP9 as inducers of Ca2+ release in DRG neurons via PAR1 and PLC activation, revealing a novel role for MMP signaling in sensory neurons during inflammation.

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk

The paper maps cell-type-specific eQTLs in IBD patients to identify effector genes and mechanisms linking genetic risk to disease.

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn's disease

This study uses single-cell RNA sequencing to analyze immune cell transcriptional profiles in mucosal and circulatory compartments of Crohn's disease patients, revealing tissue-specific inflammation signatures and identifying circulating T cells with mucosal-like features.

Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis

The paper identifies inflammation-associated monocytes (IAMs) in IBD and experimental colitis, showing they express ACOD1 to limit cytokine production during inflammation.

Transcriptomic profiling reveals a pro-nociceptive role for Angiotensin II in inflammatory bowel disease

This study identifies Angiotensin II as a pro-nociceptive mediator in IBD by showing increased Agt expression and AT1 receptor activation in colonic neurons.

KV7 but not dual SK/IK channel openers inhibit the activation of colonic afferents by noxious stimuli

The paper shows that KV7 channel openers, but not SK/IK channel openers, reduce colonic afferent responses to noxious stimuli, suggesting KV7 channels as potential targets for abdominal pain treatment.

Somatic evolution in non-neoplastic IBD-affected colon

The paper analyzes somatic mutations in colonic crypts of IBD patients and controls, finding higher mutation rates and clonal expansions in IBD-affected tissue.